Cat. No.: X24-05-ZQ637
EGFR-HER2 inhibitor Poziotinib, Purity ≥98%
Synonym: 1092364-38-9; HM781-36B; NOV120101; NOV-120101; NOV 120101; EGFR-HER2 inhibitor
- CAS Number: 1092364-38-9
- Compound CID: 25127713
Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
Poziotinib, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets HER1, HER2, and HER4.
Molecular Formula
C23H21Cl2FN4O3
Targets
HER1: 3.2 nM; HER2: 5.3 nM; HER4: 23.5 nM
Solubility
DMSO: 84 mg/mL (170.96 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Poziotinib is investigated in research exploring its broad activity as an irreversible EGFR/HER2 inhibitor in various cancers.
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