CO-1686, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR(L858R)/T790M and EGFRT790M.
CO-1686 can be used to study its efficacy as a mutant-selective EGFR inhibitor, especially in non-small cell lung cancer.
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