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FGFR inhibitor XL-228, Purity ≥98%
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Cat. No.: X23-10-ZQ490

FGFR inhibitor XL-228, Purity ≥98%

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Synonym: XL228; XL-228; 898280-07-4; XL 228; 4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine; Exel-2280; 33M2XSK003; FGFR inhibitor

  • CAS Number: 898280-07-4
  • Compound CID: 59757974
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
XL-228, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets Aurora A and IGF-1R.
Molecular Weight
437.5
Molecular Formula
C22H31N9O
Targets
Aurora A: 3.1 nM; IGF-1R: 1.6 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 79 mg/mL (180.55 mM); Water: Insoluble; Ethanol: 27 mg/mL (61.7 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
XL-228 is useful in analyzing the effects of multi-kinase inhibition, including Aurora kinases, on cancer cells.
Publications
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