CPI-169, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets EZH1, EZH2 WT, and EZH2 Y641N.
CPI-169 can be used to inhibit EZH2, thereby affecting gene silencing and potential cancer pathways.
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