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HMT inhibitor EPZ-5676, Purity ≥98%
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Cat. No.: X24-05-ZQ511

HMT inhibitor EPZ-5676, Purity ≥98%

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Synonym: 1380288-87-8; EPZ5676; EPZ 5676; Pinometostat; Histone methyltransferase inhibitor

  • CAS Number: 1380288-87-8
  • Compound CID: 57345410
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
EPZ-5676, soluble in warmed DMSO and warmed ethanol and insoluble in water, inhibits the enzymes that add methyl groups to histone proteins, altering chromatin structure and gene expression. It targets DOT1L.
Molecular Weight
562.7
Molecular Formula
C30H42N8O3
Targets
DOT1L: 80 pM (Ki)
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 88 mg/mL (156.38 mM); Water: Insoluble; Warmed ethanol: 81 mg/mL (143.94 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
EPZ-5676 can be used to inhibit DOT1L, specifically blocking H3K79 methylation and affecting leukemia cells.
Publications
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