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Cat. No.: X26-02-ZQ4707

Lipid IVA

Synonym: [(3S,5S,6R)-3-hydroxy-2-[[(2R,3S,5S)-6-(hydroxymethyl)-3-[[(3R)-3-hydroxytetradecanoyl]amino]-4-[(3R)-3-hydroxytetradecanoyl]oxy-5-phosphonooxyoxan-2-yl]oxymethyl]-5-[[(3R)-3-hydroxytetradecanoyl]amino]-6-phosphonooxyoxan-4-yl] (3R)-3-hydroxytetradecanoate

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Product Size
1 mg; 10 mg; 25 mg; 100 mg
Price
Datasheet
MSDS
Properties
Description
Lipid IVA is a tetra-acylated disaccharide precursor of Lipid A that displays species-specific activity toward the TLR4-MD2 complex. It is a cornerstone reagent for immunological research, acting as an agonist in mice but often as an antagonist in human cells.
Molecular Weight
1405.7
Molecular Formula
C68H130N2O23P2
Source
Chemical synthesis
Form
Solid or liquid
Purity
≥90%
Identity
Confirmed by NMR/HPLC/MS.
Applications
Lipid IVA can be used as a biosynthetic intermediate to study the competitive antagonism or agonism of TLR4 signaling across different species.
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