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MDM2 inhibitor HDM201, Purity ≥98%
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Cat. No.: X23-10-ZQ139

MDM2 inhibitor HDM201, Purity ≥98%

Synonym: 1448867-41-1; Siremadlin; HDM-201; HDM201; NVP-HDM 201; NVP-HDM201; Siremadlin [USAN]; (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one; MDM2 inhibitor

  • CAS Number: 1448867-41-1
  • Compound CID: 71678098
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Product Size
2 mg; 5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
MSDS
Properties
Description
HDM201, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells.
Molecular Weight
555.41
Molecular Formula
C26H24Cl2N6O4
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 98 mg/mL (176.44 mM); Water: Insoluble; Ethanol: 3 mg/mL (5.4 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
HDM201 can be studied for its capability to stabilize p53 by preventing HDM2-mediated degradation, potentially useful in cancer therapy.
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