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MDM2 inhibitor Nutlin 3a, Purity ≥98%
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Cat. No.: X23-10-ZQ133

MDM2 inhibitor Nutlin 3a, Purity ≥98%

Synonym: 675576-98-4; Nutlin-3A; Nutlin-3; Nutlin 3a; (-)-Nutlin-3; Nutlin-3a chiral; 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone; MDM2 inhibitor

  • MDL: MFCD14636430
  • CAS Number: 675576-98-4
  • Compound CID: 11433190
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
MSDS
Properties
Description
Nutlin 3a, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets p53/MDM2 interaction.
Molecular Weight
581.49
Molecular Formula
C30H30Cl2N4O4
Targets
p53/MDM2 interaction: 90 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 98 mg/mL (168.53 mM); Water: Insoluble; Ethanol: 98 mg/mL (196.53 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Nutlin 3a can be utilized to activate p53 by disrupting its interaction with MDM2, aiding studies in apoptosis and cancer progression.
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