Nutlin 3a, soluble in DMSO and ethanol and insoluble in water, prevents the degradation of p53 by inhibiting the MDM2-p53 interaction, leading to increased p53 levels and promoting apoptosis in p53-responsive cells. It targets p53/MDM2 interaction.
Nutlin 3a can be utilized to activate p53 by disrupting its interaction with MDM2, aiding studies in apoptosis and cancer progression.
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