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PDE inhibitor, Roflumilast, Purity ≥98%
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Cat. No.: X24-08-YM484

PDE inhibitor, Roflumilast, Purity ≥98%

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Synonym: 162401-32-3; Daxas; Daliresp; 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

  • MDL: MFCD00938270
  • CAS Number: 162401-32-3
  • Compound CID: 449193
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Roflumilast, soluble in DMSO and ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of metabolism by inhibiting PDE. It targets the PDE4A1, PDE4B1, PDE4A4, and PDE4B2.
Molecular Weight
403.2
Molecular Formula
C17H14Cl2F2N2O3
Targets
PDE4A1: 0.7 nM; PDE4B1: 0.7 nM; PDE4A4: 0.9 nM; PDE4B2: 0.2 nM
Form
Lyophilized powder
Purity
≥98%
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 70 mg/mL (173.6 mM); Water: insoluble; Ethanol: 13 mg/mL (32.24 mM); In vivo: 30% PEG400 + 0.5% Tween80 + 5% propylene glycol, 28 mg/mL
Applications
Roflumilast is a metabolism inhibitor that can be used for its ability to reduce inflammation in the airways, improving lung function and reducing exacerbations in patients with COPD.
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