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PERK inhibitor GSK2606414, Purity ≥98%
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Cat. No.: X23-10-ZQ158

PERK inhibitor GSK2606414, Purity ≥98%

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Synonym: 1337531-36-8; GSK2606414; GSK 2606414; GSK-2606414; 1-(5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone; PERK inhibitor

  • MDL: MFCD25976926
  • CAS Number: 1337531-36-8
  • Compound CID: 53469448
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
GSK2606414, soluble in DMSO and ethanol and insoluble in water, disrupts UPR pathway, potentially affecting apoptosis through various downstream effects. It targets EIF2AK3 (PERK), EIF2AK1 (HRI), and EIF2AK2 (PKR).
Molecular Weight
451.44
Molecular Formula
C24H20F3N5O
Targets
EIF2AK3 (PERK): 0.4 nM; EIF2AK1 (HRI): 420 nM; EIF2AK2 (PKR): 696 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 87 mg/mL (192.71 mM); Water: Insoluble; Ethanol: 18 mg/mL (39.87 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
GSK2606414 can be used to study the inhibition of the PERK pathway and its effects on cell survival in cancer research.
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