VR23, soluble in warmed DMSO and warmed water and insoluble in ethanol, interferes with the proteasome’s ability to degrade proteins, thereby disrupting cellular processes in cancer cells, particularly multiple myeloma. It targets Caspase-like proteasomes, Chymotrypsin-like proteasomes, and trypsin-like proteasomes.
VR23 is used in research to investigate and inhibit proteasome activity, which is key in regulating protein degradation and cellular processes.
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