Sitaxsentan sodium (TBC-11251) inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets ET-A, and ET-A.
Molecular Weight
476.89
Molecular Formula
C18H14ClN2NaO6S2
Targets
ET-A: 1.4 nM; ET-A: 0.43 nM (Ki)
Form
Lyophilized powder
Purity
>98%
Applications
Sitaxsentan sodium (TBC-11251) can be used to block the binding of endothelin to ETA receptors, thus inhibiting the vasoconstrictive and proliferative effects of endothelin.
Publications
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Publications
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