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Bcr-Abl inhibitor DCC-2036, Purity ≥98%

Cat. No.: X24-06-ZQ444

Bcr-Abl inhibitor DCC-2036, Purity ≥98%

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Synonym: 1020172-07-9; Bcr-Abl inhibitor; DCC2036

  • MDL: MFCD19443646
  • CAS Number: 1020172-07-9
  • Compound CID: 25066467
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
DCC-2036, soluble in DMSO and ethanol and insoluble in water, specifically inhibits the activity of the Bcr-Abl tyrosine kinase. It targets Abl1 (H396P), p-Abl1 (native), AuroraA, c-Kit, CDK2/CyclinD, FGR, FLT3, HCK, KDR, Lyn, and p-Abl1(T315I).
Molecular Weight
553.59
Molecular Formula
C30H28FN7O3
Targets
Abl1 (H396P): 1.4 nM; p-Abl1 (native): 2 nM; AuroraA: >5 μM; c-Kit: 481 nM; CDK2/CyclinD: >5 μM; FGR: 38 nM; FLT3: 2 nM; HCK: 40 nM; KDR: 4 nM; Lyn: 29 nM; p-Abl1 (T315I): 4 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 103 mg/mL (186.05 mM); Water: Insoluble; Ethanol: 15 mg/mL (27.09 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
DCC-2036 offers a framework for researching alternative therapies to overcome resistance in chronic myeloid leukemia.
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