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Bcr-Abl inhibitor GZD824 dimesylate, Purity ≥98%

Cat. No.: X24-06-ZQ467

Bcr-Abl inhibitor GZD824 dimesylate, Purity ≥98%

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Synonym: 1421783-64-3; Bcr-Abl inhibitor; GZD-824 Dimesylate

  • CAS Number: 1421783-64-3
  • Compound CID: 71519689
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
GZD824 dimesylate, soluble in DMSO and water and insoluble in ethanol, specifically inhibits the activity of the Bcr-Abl tyrosine kinase. It targets Abl (E255K), bl (M351T), Abl, Abl(G250E), Abl(H396P), Abl(Q252H), Abl(T315I), and Abl(Y253F).
Molecular Weight
724.77
Molecular Formula
C29H27F3N6O.2CH4O3S
Targets
Abl (E255K): 0.27 nM; bl (M351T): 0.29 nM; Abl: 0.34 nM; Abl (G250E): 0.71 nM; Abl (H396P): 0.35 nM; Abl (Q252H): 0.15 nM; Abl (T315I): 0.68 nM; Abl (Y253F): 0.35 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 93 mg/mL (128.31 mM); Water: 93 mg/mL (128.31 mM); Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
GZD824 dimesylate has a similar application, focusing on overcoming resistance in chronic myeloid leukemia.
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