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CRM1 inhibitor, KPT 335, Purity ≥98%
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Cat. No.: X24-09-YM518

CRM1 inhibitor, KPT 335, Purity ≥98%

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Synonym: 1392136-43-4; Verdinexor; 2-[(5-Chloro-2-{[4-(1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino]-N-methylbenzamide; (Z)-3-(3-(3,5-Bis-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)acrylohydrazide; (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide; CRM1 inhibitor

  • CAS Number: 1392136-43-4
  • Compound CID: 71492799
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Product Size
5 mg; 10 mg; 20 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
KPT 335, soluble in DMSO and ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of membrane transporters-ion channels by inhibiting CRM1. The molecular weight of the compound is 442.32, and its molecular formula is C18H12F6N6O.
Molecular Weight
442.32
Molecular Formula
C18H12F6N6O
Form
Lyophilized powder
Purity
≥98%
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 83 mg/mL (187.65 mM); Water: insoluble; Ethanol (warmed): 10 mg/mL; In vivo: 5% DMSO + corn oil, 14 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
KPT 335 plays a key role in promoting the accumulation of tumor suppressor proteins in the nucleus.
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