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DHFR inhibitor, Methotrexate, Purity ≥98%
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Cat. No.: X24-09-YM176

DHFR inhibitor, Methotrexate, Purity ≥98%

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Synonym: 59-05-2; MTX; Amethopterin; Abitrexate; Rheumatrex; Trexall; (2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid; DHFR inhibitor

  • MDL: MFCD00150847
  • CAS Number: 59-05-2
  • Compound CID: 126941
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Product Size
100 mg; 200 mg; 500 mg; 1 g
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Methotrexate, soluble in DMSO and insoluble in water and ethanol, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting DHFR. The molecular weight of the compound is 454.44, and its molecular formula is C20H22N8O5.
Molecular Weight
454.44
Molecular Formula
C20H22N8O5
Form
Lyophilized powder
Purity
≥98%
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO (warmed): 89 mg/mL (195.84 mM); Water: insoluble; Ethanol: insoluble; In vivo: 2% DMSO + 30% PEG 300 + 5% Tween 80 + ddH2O, 4 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
Methotrexate can be studied extensively for its potential therapeutic applications in the treatment of various cancers, including leukemia, lymphoma, and solid tumors.
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