Pemetrexed, insoluble in DMSO and ethanol and soluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting DHFR. The molecular weight of the compound is 427.41, and its molecular formula is C20H21N5O6.
Molecular Weight
427.41
Molecular Formula
C20H21N5O6
Form
Lyophilized powder
Purity
≥98%
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: insoluble; Water (warmed): 93 mg/mL (180.09 mM); Ethanol: insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Pemetrexed plays a key role in inhibiting multiple enzymes involved in folate metabolism, including DHFR, thymidylate synthase, and glycinamide ribonucleotide formyltransferase, thus disrupting DNA synthesis in cancer cells.
Publications
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Publications
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