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FAK inhibitor PF-00562271, Purity ≥98%
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Cat. No.: X24-06-ZQ500

FAK inhibitor PF-00562271, Purity ≥98%

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Synonym: 939791-38-5; FAK inhibitor; PF00562271; PF 00562271

  • MDL: MFCD14105612
  • CAS Number: 939791-38-5
  • Compound CID: 16118986
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
PF-00562271, soluble in warmed DMSO and insoluble in water and ethanol, is a FAK inhibitor that is used to block angiogenesis in diseases such as cancer. It targets CDK2/CyclinE, PYK2, Abl, Aurora A, c-Src, CDK1/CyclinB, CDK2/CyclinA, CDK3/CyclinE, CDK4, and CDK5/p35.
Molecular Weight
665.66
Molecular Formula
C21H20F3N7O3S.C6H6O3S
Targets
CDK2/CyclinE: 30 nM; PYK2: 13 nM; Abl: >1 μM; AuroraA: 145 nM; c-Src: 797 nM; CDK1/CyclinB: 58 nM; CDK2/CyclinA: 227 nM; CDK3/CyclinE: 47 nM; CDK4: >1 μM; CDK5/p35: 120 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 14 mg/mL (21.03 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
PF-00562271 is used in the investigation of FAK’s involvement in cancer progression and metastases by specifically blocking its kinase activity.
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