Cat. No.: X24-06-ZQ082
FGFR inhibitor Dovitinib lactate, Purity ≥98%
Synonym: 692737-80-7; FGFR inhibitor; CHIR-258 lactate; CHIR258; CHIR 258; TKI-258 lactate; TKI258; TKI 258
- MDL: MFCD23103506
- CAS Number: 692737-80-7
- Compound CID: 135431668
Product Size
5 mg; 10 mg; 50 mg; 100 mg
Properties
Description
Dovitinib lactate is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets c-Kit, CSF-1R, FGFR1, FGFR3, FLT3, PDGFRα, PDGFRβ, VEGFR1, VEGFR2, and VEGFR3.
Molecular Formula
C24H27FN6O4
Targets
c-Kit: 2 nM; CSF-1R: 36 nM; FGFR1: 8 nM; FGFR3: 9 nM; FLT3: 1 nM; PDGFRα: 210 nM; PDGFRβ: 27 nM; VEGFR1: 10 nM; VEGFR2: 13 nM; VEGFR3: 8 nM
Identity
Confirmed by NMR/HPLC/MS.
Applications
Dovitinib lactate is used in research to inhibit FGFR, advancing the understanding of FGFR’s involvement in cancer, especially for tumors with abnormal FGFR signaling.
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