Cat. No.: X23-10-ZQ379
FLT3 inhibitor Go 6976, Purity ≥98%
Synonym: 136194-77-9; Go 6976; GO6976; Go-6976; Goe 6976; 3-(13-Methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile; 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile; FLT3 inhibitor
- CAS Number: 136194-77-9
- Compound CID: 3501
Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
Go 6976, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3, JAK2, PKC (Rat brain), PKCα, and PKCα.
Molecular Formula
C24H18N4O
Targets
FLT3; JAK2; PKC (Rat brain): 7.9 nM; PKCα: 2.3 nM; PKCα: 6.2 nM
Solubility
Warmed DMSO: 18 mg/mL (47.69 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Go 6976 can be used to investigate the inhibition of protein kinase C (PKC) isozymes, specifically PKCα and PKCβ.
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