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Cat. No.: X23-10-ZQ405

FLT3 inhibitor Pacritinib, Purity ≥98%

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Synonym: Pacritinib; 937272-79-2; Pacritinib (SB1518); SB1518; SB-1518; ONX-0803; SB 1518; FLT3 inhibitor

  • MDL: MFCD22572772
  • CAS Number: 937272-79-2
  • Compound CID: 46216796
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Pacritinib, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3-D835Y, FLT3 wt, JAK1, JAK2 (V617F), JAK2wt, JAK3, and Tyk2.
Molecular Weight
472.58
Molecular Formula
C28H32N4O3
Targets
FLT3-D835Y: 6 nM; FLT3 wt: 22 nM; JAK1: 1280 nM; JAK2 (V617F): 19 nM; JAK2wt: 23 nM; JAK3: 520 nM; Tyk2: 50 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 10 mg/mL (21.15 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Pacritinib is employed in studying the selective inhibition of JAK2 and FLT3 kinases.
Publications
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