Cat. No.: X23-12-YM008
Ingenol mebutate
Synonym: 75567-37-2; PEP005; PEP-005; PEP 005; Ingenol-3-angelate; I3A
- CAS Number: 75567-37-2
- PubChem CID: 6918670
Product Size
1 mg; 2 mg; 5 mg; 10 mg
Properties
Description
Ingenol mebutate (PEP005) blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKC-α, PKC-β, PKC-δ, PKC-ε, and PKC-γ.
Molecular Formula
C25H34O6
Targets
PKC-α: 0.3 nM; PKC-β: 0.105 nM; PKC-δ: 0.376 nM; PKC-ε: 0.171 nM; PKC-γ: 0.162 nM
Applications
Ingenol mebutate (PEP005) can be used for its effect on inducing cell death in abnormal keratinocytes, which are characteristic of AK lesions.
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