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LRRK2 inhibitor, GNE-7915, Purity ≥98%
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Cat. No.: X24-09-YM701

LRRK2 inhibitor, GNE-7915, Purity ≥98%

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Synonym: 1351761-44-8; GNE7915; GMS 7915; [4-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone; LRRK2 inhibitor

  • MDL: MFCD25977005
  • CAS Number: 1351761-44-8
  • Compound CID: 58539171
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Product Size
10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
GNE-7915, soluble in DMSO and insoluble in water and ethanol, is an effective autophagy signaling inhibitor, that has the ability to prevent the pathway of autophagy signaling by inhibiting LRRK2. The molecular weight of the compound is 443.395, and its molecular formula is C19H21F4N5O3. It targets the LRRK2 and LRRK2.
Molecular Weight
443.395
Molecular Formula
C19H21F4N5O3
Targets
LRRK2
Form
Lyophilized powder
Purity
≥98%
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO (warmed): 21 mg/mL (47.36 mM); Water: insoluble; Ethanol: insoluble; In vivo: 5% DMSO + 30% PEG 300 + 5% Tween 80 + ddH2O 2.9 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
GNE-7915 can be used for its ability to ameliorate Parkinson’s disease symptoms by inhibiting the toxic effects of LRRK2 mutations.
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