LRRK2-IN-1, soluble in DMSO and ethanol and insoluble in water, is an effective autophagy signaling inhibitor, that has the ability to prevent the pathway of autophagy signaling by inhibiting LRRK2. The molecular weight of the compound is 570.09, and its molecular formula is C31H38N8O3. It targets the LRRK2(G2019S), LRRK2(WT), DCLK1 and DCLK2.
Molecular Weight
570.09
Molecular Formula
C31H38N8O3
Targets
LRRK2 (G2019S)
Form
Lyophilized powder
Purity
≥98%
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 97 mg/mL (169.96 mM); Water: insoluble; Ethanol: 97 mg/mL (169.96 mM); In vivo: Captisol, 16 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
LRRK2-IN-1 can be studied extensively for its potential therapeutic applications in the treatment of Parkinson’s by reducing LRRK2 activity, which may help in mitigating neurodegeneration.
Publications
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Publications
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