Properties
Description
NH125, soluble in DMSO and ethanol and insoluble in water, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets CaMKII, eEF-2 kinase, PKA, and PKC.
Molecular Formula
C27H45IN2
Targets
CaMKII: >100 μM; eEF-2 kinase: 60 nM; PKA: 80 μM; PKC: 7.5 μM
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Solubility
DMSO: 89 mg/mL (169.66 mM); Water: insoluble; Ethanol: 89 mg/mL (169.66 mM)
Applications
NH125 can be used to help develop potential therapeutic strategies for certain diseases, such as inflammatory disease, fibrotic diseases, and cancer.
Storage
Store at -20℃, and keep desiccated.
