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PDGFR inhibitor AMG-706 diphosphate, Purity ≥98%
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Cat. No.: X24-06-ZQ247

PDGFR inhibitor AMG-706 diphosphate, Purity ≥98%

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Synonym: 857876-30-3; PDGFR inhibitor; AMG-706

  • MDL: MFCD12407403
  • CAS Number: 857876-30-3
  • Compound CID: 16097729
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
AMG-706, soluble in warmed DMSO and warmed water and insoluble in ethanol, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets VEGFR2, VEGFR2/Flk1, EGFR, FGFR, Kit, p38, PDGFR, RET, Src, VEGFR1, and VEGFR3.
Molecular Weight
569.4
Molecular Formula
C22H23N5O.2H3PO4
Targets
VEGFR2: 3 nM; VEGFR2/Flk1: 6 nM; EGFR: >3 μM; FGFR: >2.8 μM; Kit: 8 nM; p38: >3 μM; PDGFR: 84 nM; RET: 59 nM; Src: >3 μM; VEGFR1: 2 μM; VEGFR3: 6 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 88 mg/mL (154.54 mM); Warmed water: 17 mg/mL (29.85 mM); Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
AMG-706 (Motesanib) inhibits multiple kinases including VEGFR and PDGFR, usefully contributing to integrated cancer therapy research.
Publications
Publications (0)

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