PDGFR inhibitor AMG-706 diphosphate, Purity ≥98%

Synonym: 857876-30-3; PDGFR inhibitor; AMG-706

MDL: MFCD12407403
CAS Number: 857876-30-3
Compound CID: 16097729

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

AMG-706, soluble in warmed DMSO and warmed water and insoluble in ethanol, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets VEGFR2, VEGFR2/Flk1, EGFR, FGFR, Kit, p38, PDGFR, RET, Src, VEGFR1, and VEGFR3.

Molecular Weight

569.4

Molecular Formula

C₂₂H₂₃N₅O.2H₃PO₄

Targets

VEGFR2: 3 nM; VEGFR2/Flk1: 6 nM; EGFR: >3 μM; FGFR: >2.8 μM; Kit: 8 nM; p38: >3 μM; PDGFR: 84 nM; RET: 59 nM; Src: >3 μM; VEGFR1: 2 μM; VEGFR3: 6 nM

Form

Lyophilized powder

Purity

Solubility

Warmed DMSO: 88 mg/mL (154.54 mM); Warmed water: 17 mg/mL (29.85 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AMG-706 (Motesanib) inhibits multiple kinases including VEGFR and PDGFR, usefully contributing to integrated cancer therapy research.