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PDGFR inhibitor KRN 633, Purity ≥98%
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Cat. No.: X24-06-ZQ131

PDGFR inhibitor KRN 633, Purity ≥98%

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Synonym: 286370-15-8; PDGFR inhibitor; KRN633; KRN-633

  • MDL: MFCD14155620
  • CAS Number: 286370-15-8
  • Compound CID: 9549295
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
KRN 633, soluble in DMSO and insoluble in ethanol and water, blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets VEGFR1, VEGFR2, BTK, c-Kit, PDGFRα, PDGFRβ, Tie-2, and VEGFR3.
Molecular Weight
416.9
Molecular Formula
C20H21ClN4O4
Targets
VEGFR1: 170 nM; VEGFR2: 160 nM; BTK: 9200 nM; c-Kit: 4330 nM; PDGFRα: 965 nM; PDGFRβ: 9850 nM; Tie-2: 9900 nM; VEGFR3: 125 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 8 mg/mL (19.18 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
KRN 633 acts as a PDGFR inhibitor, supporting research into therapies that hinder cancer progression through growth factor signaling.
Publications
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