PHA 291639 blocks the activity of platelet-derived growth factor receptors (PDGFR), which play a crucial role in cell growth, angiogenesis, and tissue. It targets Flk-1 and PDGFRβ.
Molecular Weight
396.46
Molecular Formula
C22H25FN4O2
Targets
Flk-1: 6 nM (Ki); PDGFRβ: 5 nM (Ki)
Form
Lyophilized powder
Purity
≥98%
Identity
Confirmed by NMR/HPLC/MS.
Applications
PHA 291639 acts as a PDGFR inhibitor and is used in studies investigating the interruption of signal pathways involved in oncogenesis.
Publications
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Publications
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