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PI3K inhibitor BKM120, Purity ≥98%
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Cat. No.: X24-05-ZQ079

PI3K inhibitor BKM120, Purity ≥98%

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Synonym: 944396-07-0; NVP-BKM120; Buparlisib; PI3K inhibitor

  • CAS Number: 944396-07-0
  • Compound CID: 16654980
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
BKM120, soluble in DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets p110β, p110δ, DNA-PK, mTOR, p110α, p110γ, PI4Kβ, and Vps34.
Molecular Weight
410.4
Molecular Formula
C18H21F3N6O2
Targets
p110β: 166 nM; p110δ: 116 nM; DNA-PK: >5 μM; mTOR: 4.6 μM; p110α: 52 nM; p110γ: 262 nM; PI4Kβ: >25 μM; Vps34: 2.4 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 76 mg/mL (185.18 mM); Water: Insoluble; Ethanol: 2 mg/mL (4.87 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
BKM120 is employed in research as a pan-PI3K inhibitor, aiding in the study of PI3K's role in cancer progression and therapy.
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