Cat. No.: X24-05-ZQ166
PI3K inhibitor TGR-1202, Purity ≥98%
Synonym: 1532533-67-7; Umbralisib; RP5264; TGR1202; TGR 1202; RP-5264; RP 5264; PI3K inhibitor
- CAS Number: 1532533-67-7
- Compound CID: 72950888
Product Size
5 mg; 10 mg; 50 mg
Properties
Description
TGR-1202, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kβ, PI3Kδ, PI3Kδ, and PI3Kγ.
Molecular Formula
C31H24F3N5O3
Targets
PI3Kα: >10000 nM (Kd); PI3Kβ: >10000 nM (Kd); PI3Kδ: 22.2 nM (EC50); PI3Kδ: 6.2 nM (Kd); PI3Kγ: 1400 nM (Kd)
Solubility
Warmed DMSO: 92 mg/mL (160.96 mM); Water: Insoluble; Warmed ethanol: 6 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
TGR-1202 is used to investigate the selective inhibition of PI3Kδ and its implications in B-cell malignancies and autoimmune disorders.
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