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PI3K inhibitor XL147 analogue, Purity ≥98%

Cat. No.: X24-05-ZQ175

PI3K inhibitor XL147 analogue, Purity ≥98%

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Synonym: 956958-53-5; XL-147; SAR245408; PI3K inhibitor

  • CAS Number: 956958-53-5
  • Compound CID: 1893730
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Product Size
10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
XL147 analogue, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kδ, B-Raf/C-Raf, DNA-PK, MEK, mTOR, PI3Kβ, PI3Kγ, and Vps34.
Molecular Weight
448.5
Molecular Formula
C21H16N6O2S2
Targets
PI3Kα: 39 nM; PI3Kδ: 36 nM; B-Raf/C-Raf: >10 μM; DNA-PK: 4.75 μM; MEK: >10 μM; mTOR: >15 μM; PI3Kβ: 383 nM; PI3Kγ: 23 nM; Vps34: 6.975 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 3 mg/mL (6.68 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
XL147 analogue can be employed to study the inhibition of PI3K signaling and its therapeutic potential in cancer research.
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