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Ro 31-8220
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Cat. No.: X23-12-YM065

Ro 31-8220

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Synonym: 125314-64-9; Bisindolylmaleimide IX; Ro31-8220

  • CAS Number: 125314-64-9
  • PubChem CID: 5083
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Product Size
1 mg; 5 mg; 10 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Ro 31-8220 blocks the function of Smad proteins in the TGF-β signaling pathway. It targets GSK3β, MAPKAP-K1b, MSK1, PKC-α, PKC-βI, PKC-βII, PKC-ε, PKC-γ, rat brain PKC, and S6K1.
Molecular Weight
457.55
Molecular Formula
C25H23N5O2S
Targets
GSK3β: 38 nM; MAPKAP-K1b: 3 nM; MSK1: 8 nM; PKC-α: 5 nM; PKC-βI: 24 nM; PKC-βII: 14 nM; PKC-ε: 24 nM; PKC-γ: 27 nM; Rat brain PKC: 23 nM; S6K1: 15 nM
Form
Lyophilized powder
Purity
>98%
Applications
Ro 31-8220 can be used to inhibit abnormal mast cell proliferation and reduce symptoms associated with mast cell activation, such as skin lesions, gastrointestinal disturbances, and anaphylaxis.
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