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ROCK inhibitor Fasudil HCl, Purity ≥98%

Cat. No.: X23-10-ZQ800

ROCK inhibitor Fasudil HCl, Purity ≥98%

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Synonym: Fasudil hydrochloride; 105628-07-7; Fasudil HCl; Eril; Fasudil (HA-1077) HCl; 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride; Fasudil (Hydrochloride); ROCK inhibitor

  • MDL: MFCD00943198
  • CAS Number: 105628-07-7
  • Compound CID: 163751
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Product Size
250 mg; 500 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Fasudil HCl, soluble in DMSO and water and insoluble in ethanol, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets MLCK, PKA, PKC, PKG, and ROCK2.
Molecular Weight
327.8
Molecular Formula
C14H17N3O2S.HCl
Targets
MLCK: 36 μM (Ki); PKA: 1.6 μM (Ki); PKC: 3.3 μM (Ki); PKG: 1.6 μM (Ki); ROCK2: 330 nM (Ki)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 5 mg/mL (15.25 mM); Water: 60 mg/mL (183.02 mM); Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Fasudil HCl can be used to examine its role as a Rho kinase inhibitor and its potential therapeutic applications in cardiovascular diseases and neurological disorders.
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