Properties
                                        
                            Description
                            RKI-1447, soluble in DMSO and insoluble in ethanol and water, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK1 and ROCK2.
                         
                                                                            
                                                            
                            Molecular Formula
                            C16H14N4O2S
                         
                                                                                                                                            
                            Targets
                            ROCK1: 14.5 nM; ROCK2: 6.2 nM
                         
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
                                                            
                                                                                                                                                                            
                            Solubility
                            DMSO: 62 mg/mL (189.97 mM); Water: Insoluble; Ethanol: Insoluble
                         
                                                            
                            Identity
                            Confirmed by NMR/HPLC/MS.
                         
                                                                                                                                                            
                            Applications
                            RKI-1447 is utilized to investigate its inhibitory effects on ROCK1 and ROCK2 in the study of cell migration and invasion.