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Ruboxistaurin hydrochloride
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Cat. No.: X23-12-YM052

Ruboxistaurin hydrochloride

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Synonym: 169939-93-9; LY-333531

  • CAS Number: 169939-93-9
  • PubChem CID: 9870785
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Product Size
2 mg; 5 mg; 10 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Ruboxistaurin (LY333531 HCl), soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKCα, PKCβI, PKCβII, PKCδ, PKCε, PKCη, and PKCγ.
Molecular Weight
505.01
Molecular Formula
C28H28N4O3·HCl
Targets
PKCα: 360 nM; PKCβI: 4.7 nM; PKCβII: 5.9 nM; PKCδ: 250 nM; PKCε: 600 nM; PKCη: 52 nM; PKCγ: 300 nM
Form
Lyophilized powder
Purity
>98%
Solubility
DMSO: 49 mg/mL (97.02 mM); Water: insoluble; Ethanol: insoluble
Applications
Ruboxistaurin (LY333531 HCl) can be used for its efficacy in diabetic neuropathy, another complication of diabetes involving nerve damage.
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