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Cat. No.: X24-06-ZQ373

Trk receptor inhibitor GNF 5837, Purity ≥98%

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Synonym: 1033769-28-6; Trk receptor inhibitor; GNF-5837; GNF5837

  • MDL: MFCD24386809
  • CAS Number: 1033769-28-6
  • Compound CID: 59397065
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Product Size
10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
GNF 5837, soluble in DMSO and warmed ethanol and insoluble in water, blocks the activity of tropomyosin receptor kinases, which are involved in the growth and survival of neurons. It targets TrkA, TrkB, Abl, ALK, CSF-1R, FGFR3, FGFR4, FLT3, IGF-1R, Insulin receptor, and JAK2.
Molecular Weight
535.49
Molecular Formula
C28H21F4N5O2
Targets
TrkA: 11 nM; TrkB: 9 nM; Abl: 8.2 nM; ALK: 3.4 nM; CSF-1R: 4 μM; FGFR3: 9.3 μM; FGFR4: 7 μM; FLT3: 5.1 μM; IGF-1R: 7.6 μM; Insulin receptor: 8 μM; JAK2: 2.9 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 92 mg/mL (171.8 mM); Water: Insoluble; Warmed ethanol: 8 mg/mL (14.93 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
GNF 5837 is examined for its role in inhibiting Trk kinases, relevant in researching treatments for cancers and neurological disorders.
Publications
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