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Trk receptor inhibitor MGCD516, Purity ≥98%
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Cat. No.: X24-06-ZQ382

Trk receptor inhibitor MGCD516, Purity ≥98%

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Synonym: 1123837-84-2; Trk receptor inhibitor; MGCD516; MG516

  • CAS Number: 1123837-84-2
  • Compound CID: 25212148
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Product Size
5 mg; 10 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
MGCD516, soluble in DMSO and ethanol and insoluble in water, blocks the activity of tropomyosin receptor kinases, which are involved in the growth and survival of neurons. It targets Axl, DDR1, DDR2, FLT3, KIT, Mer, TrkA, TrkB, VEGFR1, VEGFR2, and VEGFR3.
Molecular Weight
629.68
Molecular Formula
C33H29F2N5O4S
Targets
Axl: 1.5 nM; DDR1: 29 nM; DDR2: 0.5 nM; FLT3: 8 nM; KIT: 6 nM; Mer: 2 nM; TrkA: 5 nM; TrkB: 9 nM; VEGFR1: 6 nM; VEGFR2: 5 nM; VEGFR3: 2 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 98 mg/mL (155.63 mM); Water: Insoluble; Ethanol: 98 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
MGCD516 is employed in the study of multiple kinase pathways including MET, VEGFR, and TRK, relevant for cancer therapy research.
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