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VEGFR inhibitor Axitinib, Purity ≥98%
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Cat. No.: X24-06-ZQ233

VEGFR inhibitor Axitinib, Purity ≥98%

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Synonym: 319460-85-0; VEGFR inhibitor; AG 013736

  • MDL: MFCD09837898
  • CAS Number: 319460-85-0
  • Compound CID: 6450551
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Product Size
50 mg; 100 mg; 250 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Axitinib, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets VEGFR2/Flk1, VEGFR2/KDR, CSF-1R, FLT3, Kit, PDGFRα, PDGFRβ, VEGFR1/FLT1, and VEGFR3.
Molecular Weight
386.5
Molecular Formula
C22H18N4OS
Targets
VEGFR2/Flk1: 0.18 nM; VEGFR2/KDR: 0.2 nM; CSF-1R: 73 nM; FLT3: >1 μM; Kit: 1.7 nM; PDGFRα: 5 nM; PDGFRβ: 1.6 nM; VEGFR1/FLT1: 0.1 nM; VEGFR3: 0.1-0.3 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 30 mg/mL (77.62 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Axitinib acts on VEGFR, relevant in cancer research for its role in blocking blood supply to tumors.
Publications
Publications (0)

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