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VEGFR inhibitor ENMD-2076, Purity ≥98%
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Cat. No.: X23-10-ZQ468

VEGFR inhibitor ENMD-2076, Purity ≥98%

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Synonym: ENMD-2076; 934353-76-1; ENMD 2076; (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine; ENMD2076; VEGFR inhibitor

  • MDL: MFCD18074523
  • CAS Number: 934353-76-1, 1291074-87-7
  • Compound CID: 16041424
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
ENMD-2076, soluble in DMSO and water and insoluble in ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets Aurora A, RET, Abl1 (T315I), Aurora B, BLK, CSF-1R/c-Fms, FAK, FGFR1, FGFR2, FLT3, and Fyn.
Molecular Weight
375.5
Molecular Formula
C21H25N7
Targets
Aurora A: 14 nM; RET: 10.4 nM; Abl1 (T315I): 81.3 nM; Aurora B: 350 nM; BLK: 69.4 nM; CSF-1R/c-Fms: 24.8 nM; FAK: 54.9 nM; FGFR1: 92.7 nM; FGFR2: 70.8 nM; FLT3: 1.86 nM; Fyn: 112 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 101 mg/mL (268.99 mM); Water: 1 mg/mL (2.66 mM); Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
ENMD-2076 can be used to investigate the inhibition of Aurora kinase A and angiogenesis in cancer studies.
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