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Bcl-2 inhibitor ABT-737, Purity ≥98%
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Cat. No.: X23-10-ZQ002

Bcl-2 inhibitor ABT-737, Purity ≥98%

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Synonym: 852808-04-9; ABT-737; ABT 737; ABT737; UNII-Z5NFR173NV; 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide; Bcl-2 inhibitor

  • MDL: MFCD12756212
  • CAS Number: 852808-04-9
  • Compound CID: 11228183
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
ABT-737, soluble in DMSO and insoluble in ethanol and water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Bcl-2, Bcl-B, Bcl-w, Bcl-xL, Bfl-1, and Mcl-1.
Molecular Weight
813.4
Molecular Formula
C42H45ClN6O5S2
Targets
Bcl-2: 30.3 nM; Bcl-B: 1.82 μM (EC50); Bcl-w: 197.8 nM (EC50); Bcl-xL: 78.7 nM (EC50); Bfl-1: >10 uM (EC50); Mcl-1: >10 uM (EC50)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 92 mg/mL (113.1 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
ABT-737 can be used to study the role of BCL-2 family proteins in cancer and to develop combination therapies.
Publications
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