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Bcl-2 inhibitor Navitoclax, Purity ≥98%
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Cat. No.: X23-10-ZQ001

Bcl-2 inhibitor Navitoclax, Purity ≥98%

Synonym: 923564-51-6; Navitoclax; ABT-263; ABT-263 (Navitoclax); (R)-4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide; Bcl-2 inhibitor

  • MDL: MFCD12756219
  • CAS Number: 923564-51-6
  • Compound CID: 24978538
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
MSDS
Properties
Description
Navitoclax, soluble in DMSO and insoluble in ethanol and water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Bcl-xL, Bcl-2, Bcl-w, A1, and Mcl-1.
Molecular Weight
974.6
Molecular Formula
C47H55ClF3N5O6S3
Targets
Bcl-xL: ≤0.5 nM (Ki); Bcl-2: ≤1 nM (Ki); Bcl-w: ≤1 nM (Ki); A1: 354 nM (Ki); Mcl-1: 550 nM (Ki)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 89 mg/mL (91.31 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Navitoclax can be used to study in the context of hematologic malignancies and some solid tumors.
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