Cat. No.: X23-10-ZQ007
Bcl-2 inhibitor Venetoclax, Purity ≥98%
Synonym: 1257044-40-8; Venetoclax; ABT-199; Venclexta; GDC-0199; ABT199; ABT 199; 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; Bcl-2 inhibitor
- MDL: MFCD23160052
- CAS Number: 1257044-40-8
- Compound CID: 49846579
Product Size
10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
Venetoclax, soluble in warmed DMSO and insoluble in water and ethanol, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Bcl-2, Bcl-xL, Bcl-w, and Mcl-1.
Molecular Formula
C45H50ClN7O7S
Targets
Bcl-2: 444 nM (Ki); Bcl-xL; Bcl-w; Mcl-1
Solubility
Warmed DMSO: 93 mg/mL (107.08 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Venetoclax can be used to research the therapy in certain types of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).
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