AMD 3465 Hexahydrobromide, soluble in DMSO and water and insoluble in ethanol, is a potent, selective CXCR4 antagonist. It targets 12G5 mAb-CXCR4, CXCL12AF647-CXCR4, HIV-2 (EHO), HIV-2 (ROD), X4 HIV-1 (HE), X4 HIV-1 (IIIB), X4 HIV-1 (NL4.3), X4 HIV-1 (NL4.3AMD3100), and X4 HIV-1 (RF).
Molecular Weight
896.07
Molecular Formula
C24H38N6.6HBr
Targets
12G5 mAb-CXCR4: 0.75 nM; CXCL12AF647-CXCR4: 18 nM (In SupT1 cells); HIV-2 (EHO); HIV-2 (ROD): 12.3 nM (In MT-4 cells); X4 HIV-1 (HE): 9.8 nM (In MT-4 cells); X4 HIV-1 (IIIB): 12.3 nM (In MT-4 cells); X4 HIV-1 (NL4.3): 6.1 nM (In MT-4 cells); X4 HIV-1 (NL4.3AMD3100): 2822 nM (In MT-4 cells); X4 HIV-1 (RF): 7.4 nM (In MT-4 cells)
AMD 3465 Hexahydrobromide can be used to explore its application as a CXCR4 antagonist in cancer and HIV research.
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