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CXCR antagonist SCH-527123, Purity ≥98%
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Cat. No.: X23-10-ZQ526

CXCR antagonist SCH-527123, Purity ≥98%

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Synonym: Navarixin; 473727-83-2; SCH 527123; SCH-527123; Sch527123; (R)-2-Hydroxy-N,N-dimethyl-3-((2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)benzamide; CXCR antagonist

  • CAS Number: 473727-83-2
  • Compound CID: 9865554
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
SCH-527123, soluble in DMSO and ethanol and insoluble in water, is an active CXCR antagonist. It targets 125I-CXCL8-CXCR1, 125I-CXCL8-CXCR2, Cynomolgus CXCR1, Cynomolgus CXCR2, mouse CXCR2, and rat CXCR2.
Molecular Weight
397.42
Molecular Formula
C21H23N3O5
Targets
125I-CXCL8-CXCR1: 43 nM; 125I-CXCL8-CXCR2: 0.97 nM; Cynomolgus CXCR1: 41 nM (Kd); Cynomolgus CXCR2: 0.08 nM (Kd); Mouse CXCR2: 0.2 nM (Kd); Rat CXCR2: 0.2 nM (Kd)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 71 mg/mL (178.65 mM); Water: Insoluble; Ethanol: 71 mg/mL (178.65 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
SCH-527123 can be used to investigate the inhibition of chemokine receptors CXCR1 and CXCR2 in inflammation.
Publications
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