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CXCR inhibitor AMG 487, Purity ≥98%
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Cat. No.: X23-10-ZQ724

CXCR inhibitor AMG 487, Purity ≥98%

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Synonym: AMG 487; 473719-41-4; AMG-487; 355CGR2CBL; CHEMBL397983; (R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide; CXCR inhibitor

  • CAS Number: 473719-41-4
  • Compound CID: 24957182
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
AMG 487, soluble in DMSO and ethanol and insoluble in water, targets the chemokine receptors CXCR, which are part of the GPCR family. It targets 125I-IP10-CXCR3 and 125I-ITAC-CXCR3.
Molecular Weight
603.59
Molecular Formula
C32H28F3N5O4
Targets
125I-IP10-CXCR3: 8 nM; 125I-ITAC-CXCR3: 8.2 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 97 mg/mL (160.7 mM); Water: Insoluble; Ethanol: 97 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
AMG 487 is a CXCR3 antagonist used to study its role in immune cell trafficking and inflammatory diseases.
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