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DNA-PK inhibitor AZD-7648, Purity ≥98%
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Cat. No.: X24-05-ZQ230

DNA-PK inhibitor AZD-7648, Purity ≥98%

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Synonym: 2230820-11-6; AZD7648; AZD 7648; DNA-PK inhibitor

  • CAS Number: 2230820-11-6
  • Compound CID: 135151360
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Product Size
5 mg; 10 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
AZD-7648, soluble in DMSO and insoluble in ethanol and water, impairs the non-homologous end joining (NHEJ) pathway of DNA repair, thereby sensitizing cancer cells to treatments that induce DNA double-strand breaks. It targets ATM, DNA-PKcs, and PI3Kγ.
Molecular Weight
380.4
Molecular Formula
C18H20N8O2
Targets
ATM: 17.93 μM; DNA-PKcs: 91.3 μM; PI3Kγ: 1.37 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 5 mg/mL (13.14 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
AZD-7648 can be used to investigate its role as an inhibitor of DNA-dependent protein kinase (DNA-PK) in cancer therapy.
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