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EGFR-HER2 inhibitor Afatinib dimaleate, Purity ≥98%
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Cat. No.: X24-05-ZQ650

EGFR-HER2 inhibitor Afatinib dimaleate, Purity ≥98%

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Synonym: 850140-73-7; BIBW 2992MA2; BIBW-2992; BIBW2992; BIBW 2992; Afatinib; EGFR-HER2 inhibitor

  • CAS Number: 850140-73-7
  • Compound CID: 15606394
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Product Size
25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Afatinib dimaleate, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR (L858R), EGFR (L858R/T790M), EGFR (wt), and HER2.
Molecular Weight
718.08
Molecular Formula
C32H33ClFN5O11
Targets
EGFR (L858R): 0.4 nM; EGFR (L858R/T790M): 10 nM; EGFR (wt): 0.5 nM; HER2: 14 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 87 mg/mL (121.3 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Afatinib dimaleate is used for its irreversible inhibition of the ErbB family of receptors in studies on various cancers.
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