Cat. No.: X24-05-ZQ673
EGFR-HER2 inhibitor Afatinib, Purity ≥98%
Synonym: 850140-72-6; BIBW 2992; BIBW-2992; BIBW2992; EGFR-HER2 inhibitor
- CAS Number: 850140-72-6
- Compound CID: 10184653
Product Size
10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
Afatinib, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR, EGFR (L858R), EGFR(L858R/T790M), and HER2.
Molecular Formula
C24H25ClFN5O3
Targets
EGFR: 0.5 nM; EGFR (L858R): 0.4 nM; EGFR(L858R/T790M): 10 nM; HER2: 14 nM
Solubility
DMSO: 90 mg/mL (185.21 mM); Water: Insoluble; Ethanol: 14 mg/mL (28.8 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Afatinib can be used to investigate its role as an irreversible inhibitor of EGFR and HER2 in cancer therapy.
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