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EGFR-HER2 inhibitor AG-490, Purity ≥98%
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Cat. No.: X23-10-ZQ353

EGFR-HER2 inhibitor AG-490, Purity ≥98%

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Synonym: 133550-30-8; AG-490; Tyrphostin B42; AG 490; Tyrphostin AG 490; (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; EGFR-HER2 inhibitor

  • MDL: MFCD00236452
  • CAS Number: 133550-30-8
  • Compound CID: 5328779
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Product Size
10 mg; 25 mg; 50 mg; 100 mg; 200 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
AG-490, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB2, and JAK2.
Molecular Weight
294.3
Molecular Formula
C17H14N2O3
Targets
EGFR: 0.1 μM; ErbB2: 13.5 μM; JAK2: 10 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 54 mg/mL (183.48 mM); Water: Insoluble; Ethanol: 6 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
AG-490 can be employed to study JAK2 inhibition and its role in preventing cytokine signaling in cancer and inflammatory diseases.
Publications
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