ASP8273, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR, EGFR (Exon 19 deletion/T790M), EGFR(L858R), and EGFR(L858R/T790M).
ASP8273 can be used to study its irreversible inhibition of EGFR mutants, particularly in lung cancer models.
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